![]() “These findings support preferentially prescribing ARBs over ACE inhibitors when initiating treatment for hypertension.” ![]() “In our large-scale, observational network study, ARBs do not differ statistically significantly in effectiveness at the class level compared with ACE inhibitors as first-line treatment for hypertension but present a better safety profile,” the researchers conclude. 18% more likely to develop bleeding in the gastrointestinal tract.32% more likely to develop pancreatitis.32% more likely to develop a possibly dry, persistent cough.3.3 times more likely to develop fluid accumulation and angioedema.Specifically, compared with patients taking ARBs, those prescribed ACE inhibitors were: On the other hand, with secondary and safety outcomes, patients on ARBs had significantly lower risk of angioedema, cough, pancreatitis, and gastrointestinal bleeding. The research team also considered 51 secondary and safety outcomes, including angioedema, cough, syncope, and electrolyte abnormalities.Īmong the nearly 2.3 million patients initiating treatment with ACE inhibitors and 674,000 patients with ARBs, the researchers said they identified no statistically significant difference in the primary outcomes of acute myocardial infarction (hazard ratio, 1.11 for ACE versus ARB ), heart failure (hazard ratio, 1.03 ), stroke (hazard ratio, 1.07 ), or composite cardiovascular events (hazard ratio, 1.06 ). Defined as the primary outcomes were acute myocardial infarction, heart failure, stroke, and composite cardiovascular events. The study included all patients with hypertension initiating monotherapy with an ACE inhibitor or ARB between 19 in the international databases. Pointing out, however, that little research has compared the two, the authors sought to determine the real-world effectiveness and safety of ACE inhibitors versus ARBs in the first-line treatment of hypertension. Physical activity and other lifestyle changes are also recommended for managing all levels of high blood pressure, even if medication is suggested. The AHA/ACC 2017 Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults lists the primary medications for treating high blood pressure as thiazide diuretics, ACE inhibitors, ARBs, and calcium channel blockers. ![]() With so many medicines to choose from, we felt we could help provide some clarity and guidance to patients and health care professionals,” said lead author RuiJun Chen, MD, MA, assistant professor in translational data science and informatics at Geisinger Medical Center in Danville, Pennsylvania, and a postdoctoral fellow at Columbia University at the time of the study. “In professional guidelines, several classes of medications are equally recommended as first-line therapies. ARBs, meanwhile, help blood vessels avoid constriction by blocking receptors to which angiotensin attaches. Blood pressure is reduced because ACE inhibitors block an enzyme early in the system, resulting in lower production of angiotensin, which can narrow blood vessels. The study team looked at records for nearly 3 million patients taking a high blood pressure medication for the first time with no history of heart disease or stroke.īackground information in the articles notes that both ACE inhibitors and ARBs target the renin-angiotensin-aldosterone system. That information came from an analysis of eight electronic health-record and insurance-claim databases in the United States, Germany, and South Korea. The authors point out that, while ACE inhibitors might be prescribed more often in that situation, ARBs work as well with apparently fewer side effects. The research,published in Hypertension, focused on angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) for patients initiating antihypertensives. New York-Two commonly prescribed blood pressure medication classes appear to work equally well but notably differ on side effect profiles, according to a new study.
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![]() Here’s our list of who’s still out there, fighting the good fight against the mail-order giant who shall not be named. Now seems like a good time to take stock of the Philadelphia-area bookstore situation. He and the bookshop his dad founded were two of the all-time greats. After an amazing 70-year run, the Sansom Street spot will close its doors on Saturday not because of poor sales or rising rent, but because Michael Fox has had a good, long career and deserves a frickin’ break. Well, beloved Center City bookstore Joseph A. WEB DuBois, Black Lives 1900: W.E.B.Baldwin’s Book Barn in West Chester is on our list of Philadelphia-area bookstores. These are our best-selling titles for the last month:ĭavid Adler, Things That Float and Things That Don’tĪkwaeke Emezi You Made a Fool of Death with Your Beauty Samin Nosrat, Salt, Fat, Acid Heat: Mastering the Elements of Good CookingĬarmen Machado, Her Body and Other Partiesīernard Brown, Exploring Philly Nature: A Guide for All Four Seasons Jenny Odell, How to Do Nothing: Resisting the Attention EconomyĮsme Weijun Wang, The Collected Schizophrenias: Essays Kim Stanley Robinson, The Ministry for the Futureĭavid Graeber & David Wengrow, The Dawn of Everything: A New History of HumanityĪkwaeke Emezi, You Made a Fool of Death With Your Beauty Robin Wall Kimmerer, Gathering Moss: A Natural and Cultural History of Mosses Ocean Vuong, On Earth We’re Briefly Gorgeousĭeatra Cohen & Adam Siegel, Ashkenazi Herbalism: Recovering the Herbal Traditions of Eastern European Jews Ottessa Moshfegh, My Year of Rest and Relaxation Michelle Zauner, Crying in H-Mart: A Memoirĭaniel Laurison, Producing Politics: Inside the Exclusive Campaign World where the Privileged Few Shape Politics for All of Us Robin Wall Kimmerer, Braiding Sweetgrass: Indigenous Wisdom, Scientific Knowledge and the Teachings of Plants These are our best-selling titles for the last year: Please register for each day separately and select a virtual or in-person option. ![]() The program will be held in person with an option to join virtually. Registration for the symposium is free and open to the public. Educating a new generation in diversity and cultural heritage.Current efforts to create, publish, and disseminate inclusive children’s literature in the 21st century.The importance of storytelling through eye and ear.The work of contemporary Black artists, authors, and illustrators who knew and were influenced by Ashley Bryan.On Friday, April 7, a full day of panel discussions explores the following topics: ( Details Here) On Thursday, April 6, celebrate the official opening of the exhibition with a tour led by curator Lynne Farrington, followed by a keynote address by award-winning illustrator, artist, and author Javaka Steptoe. This symposium will bring together a range of speakers to reflect on Ashley Bryan’s legacy as an artist, teacher, children’s book author and illustrator, and citizen of the world, while looking at how his legacy is being moved forward by those inspired and mentored by him. Hybrid event: Class of 1978 Orrery Pavilion, Van Pelt-Dietrich Library Center, sixth floor and on Zoom In conjunction with the opening of the exhibition Beautiful Blackbird: The Creative Spirit of Ashley Bryan, this symposium will bring together a range of speakers to reflect on Bryan’s legacy as an artist, teacher, children’s book author, and illustrator.Īpril 6-7, 2023. Several comments recognize this “it has potential to be used for both for transaction processing as well analytical queries.”īut a couple of comments seem to reflect a view of SingleStore as an in-memory database (only) “Excellent in-memory option for high-powered data analysis,” says one. SingleStore is also unusual in its ability to handle both transactions and analytics, while replacing slow and complex extract, transform, and load (ETL) processes with easy-to-use SingleStore Pipelines. But it’s harder to understand how it works than with some single-server relational databases. So SingleStore is easy to use, compared to the big-data alternatives. The point here is that, when dealing with large volumes of data, SingleStore eliminates the need to shard your own database, or to buy in a complex and expensive solution such as Oracle Exadata, when capacity demands outstrip what can be handled on a single server. The commenters are, indeed, talking about the same database. (Not only do both databases use SQL, but SingleStore directly supports the MySQL wire protocol for connectivity.) Other commenters describe SingleStore as complicated or taking time to master “It has some learning curve,” says one. Some commenters describe it as very easy to use, and very easy to implement this is especially true for those who have MySQL experience. The only major aspect of SingleStore’s capabilities that receives mixed reviews on G2 Crowd is ease of use. Two Sides to Ease of Use, and More two-sides-to-ease-of-use-and-more Now we can analyze large amounts of data with efficiency.” “We are solving too many problems with the help of SingleStore. New features in SingleStore Universal Storage improve speed further, with smaller data size (equals faster loading times) for rowstore tables, and faster seeks and faster updating, using secondary hash indexes, for columnstore tables. SingleStore achieves its high speed through a distributed, lock-free architecture. The major focus of many comments, and a common thread through nearly all of them, is SingleStore’s speed. (Some of the comments have been lightly edited for spelling, syntax, spelling out acronyms, and so on – the original comments are on the G2 site.) Speed speed The major positive areas cited in include speed, capacity, and ease of implementation. The recent comments on G2.com have yielded a star rating of 4 out of a possible 5 points. What SingleStore Users on G2.com Say About SingleStore what-single-store-users-on-g-2-com-say-about-single-store Otherwise, you might miss comments about recommendations to others, the problems being solved, benefits being realized, and other valuable information. ![]() Note: Be sure to hit the Show More link on G2.com reviews. Your review comments encourage the vendors of products you use to keep up the good work and to fix any problems. ![]() Using G2.com will help you see whether a product is a strong player in the market assess its strengths and weaknesses look at the competition and get ready to answer intelligent questions in a vendor call. (Not a bot – at least, not last time we checked.) You can quickly share your comments on social media, ask a vendor question, or request a demo from a vendor. It’s easy to link from a product to its overarching category (such as Relational Databases Software, for SingleStore and related software, or to interact with a G2 Advisor, to help you narrow your search with help from a live person. Services categories include lawyers, tax people, sales training, graphic design, website design, staffing services, channel partners, and much more. Software categories include CRM software, demand generation software, BI tools, AI development and delivery tools, marketplace platforms, CAD/CAM tools, and many more. G2.com features information and frank user reviews of business solutions – software and services – across a wide range of categories. (Also, as most would say, of the new decade, though – as xkcd points out – this is a matter of some controversy.) However, the most recent review was in December now, some lucky SingleStore user has the chance to register the first comment of the new year. As Walt P, a data engineer at an enterprise company, puts it: “We have loaded data in volumes that have historically stopped other database technologies in their tracks.” Since our look at the site last July, dozens of new reviews have been posted, citing SingleStore’s speed, high capacity, and SQL compatibility, among other features. SingleStore is garnering a lot of positive attention on business solutions review site G2.com (formerly known as G2 Crowd). ![]() You and we have the right to know, learn, read, hear what and how we deem appropriate.Īll donations are kept completely private and confidential. You don’t need to do anything differently when there is a Super Jackpot on offer. When the jackpot starts at 130 million, it can rapidly power upwards towards record territory if nobody wins on the night. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. EuroMillions Superdraws are special because usually it requires a series of rollovers to build up a nine-figure prize. ![]() ![]() If Australia is the lucky country, then WA is. Next up is Double Win Day for Monday and Wednesday Lotto - where winners in Divisions 2-6 will have their prize doubled (13 & 15 May). That’s the ticket SEE THE LIST: WA’s biggest Lotto wins revealed. It's a LOTTO SUPER WEEK, with three super big draws for Saturday, Monday and Wednesday Lotto First up is the 20 million Superdraw on Saturday 11 May, where WA could produce it's next millionaire. The hunt continues for Western Australia’s latest millionaire a day and half after the mystery winner ticket holder scooped Thursday night’s 40 million Powerball jackpot. It is a bumpy road with all sorties of difficulties. Hunt is still on for 40 million WA lotto winner. We endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. This tendency is not only totally unacceptable, but also to a degree frightening). According to independent assessment, about 98% of the media sector is held by three conglomerates. The Australian Superdraw Every week, 5 of the prize money in Australian Lotto is held in reserve and kept in a special fund which builds up over a period of several months. Prize payouts are divided amongst all winners for each division. Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. The Australian National Lottery has six prize divisions. The same usual system and pick entries are available for Superdraws. The first 6 balls are the winning numbers, the last 2 are the supplementary numbers. Media ownership in Australia is one of the most concentrated in the world ( Learn more). Superdraws follow the same format and all the same rules as regular Saturday Lotto draws, with 8 balls drawn from a barrel containing balls ranging from 1 to 45. We don't put up a paywall – we believe in free access to information of public interest. Make sure to get involved to give yourself a chance of winning, whether you choose your numbers online or visit an authorised retailer to buy a ticket.Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. The UK has not had a jackpot winner yet this year, but the upcoming Superdraw could provide the first. The winner chose to keep their identity private. ![]() In a year of big winners, the UK’s third-largest lottery prize of all time arrived in September 2022 and was worth £171 million. They revealed that they decided to go public because they did not want the stress of having to keep such big news a secret. The UK record had previously been broken just a couple of months earlier in May 2022, when Joe and Jess Thwaite from Gloucester landed a jackpot of £184 million. The lucky winner of that jackpot came forward quickly, but opted to stay anonymous. This would set a new record, eclipsing the £195 million that was won by a UK player on 19th July last year. If the Superdraw jackpot rolls over, it would only take a few weeks for it to hit its limit of €240 million (approximately £210 million). The cost to play is the same as normal and you are still required to pick five numbers from 1 to 50, plus two Lucky Stars from 1 to 12. When the jackpot starts at €130 million, it can rapidly power upwards towards record territory if nobody wins on the night. The jackpot amount is always set in Euros as that is the currency of seven of the nine participating countries, and then it can be converted to pounds based on the exchange rate just before draw time.ĮuroMillions Superdraws are special because usually it requires a series of rollovers to build up a nine-figure prize. The precise figure will only be confirmed on the day of the draw, but it will be worth €130 million. The next EuroMillions Superdraw will go ahead on Friday 2nd June, once again putting up a guaranteed jackpot of more than £100 million.
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